Fatal familial insomnia(FFI) is a very rare prion disease of the brain. FFI has no known cure and involves progressively worsening insomnia, which eventually leads to hallucinations, delirium, and dementia-like symptoms. The average age of diagnosis is about 40 years of age and the average life span after diagnosis is 18 months. FFI is not caused by an infection, but is inherited in an autosomal dominant fashion. Knowing its inheritance pattern AND knowing it is a prion disease, which of the following is accurate?

A. Individuals with FFI have inherited a gene that encodes a mutant form of a prion protein that folds abnormally.
B. The abnormal prion protein gradually converts the normal prion proteins of the brain into abnormal prion proteins.
C. The abnormal proteins do not get degraded and they form aggregates in brain cells.
D. An individual who inherits one copy of the mutant allele will show the FFI phenotype.
E. All of these are correct.


E. All of these are correct.

Biology & Microbiology

You might also like to view...

Mesophelic crenarchaeotes (Thaumarchaeota) have been isolated ________.

A. from marine plankton B. as symbiotes of sea sponges and sea cucumbers C. as pathogens of whales and giant squid D. from rice paddies and lake sediment

Biology & Microbiology

Chromatids that are attached at the centromere are

called what kind of chromatids? a. mother b. daughter c. sister d. programmed e. either mother or daughter

Biology & Microbiology

How many unrooted trees are possible for a six-species tree and a seven-species tree, respectively?

a. 6 and 7 c. 105 and 945 b. 15 and 25 d. more than the stars in the universe

Biology & Microbiology

The main organic product of photosynthesis is

A. glucose. B. carbon dioxide. C. protein. D. triglyceride. E. chlorophyll.

Biology & Microbiology