A teenage boy has begun to exhibit the characteristic signs and symptoms of schizophrenia. During his mother's pregnancy, during what time in development could she have experienced an intrauterine insult?
A) Conception
B) First trimester
C) Second trimester
D) Third trimester
C
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The neurodevelopmental model proposes that schizophrenia results when abnormal brain synapses are formed in response to an intrauterine insult during the second trimester of pregnancy, when neuronal migration is normally taking place. At conception, no implantation in the uterus has occurred. The first trimester is prior to neuronal migration. The third trimester is after neuronal migration.
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