A child with cystic fibrosis is receiving recombinant human deoxyribonuclease (DNase). What statement about DNase is true?
a. Given subcutaneously
b. May cause voice alterations
c. May cause mucus to thicken
d. Not indicated for children younger than age 12 years
ANS: B
One of the only adverse effects of DNase is voice alterations and laryngitis. DNase is given in an aerosolized form, decreases the viscosity of mucus, and is safe for children younger than 12 years.
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