The conversion of HbO2 to deoxygenated Hb does which of the following? 1. Decreases blood carbon dioxide content. 2. Enhances carbon dioxide loading on Hb. 3. Helps buffer H+ ions
a. 2 and 3 only
b. 1 and 2 only
c. 3 only
d. 1, 2, and 3
ANS: A
Figure 12-14 shows that oxyhemoglobin saturation also affects the position of the CO2 dissocia-tion curve. The influence of oxyhemoglobin saturation on CO2 dissociation is called the Haldane effect. As previously explained, this phenomenon is a result of changes in the affinity of hemo-globin for CO2, which occur as a result of its buffering of H+ ions.
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