What is the most likely causative association between malaria and sickle cell trait?
a. Sickle gene makes people more prone to malaria infection.
b. Sickle gene prevents Plasmodium ovale infection.
c. They are both found in Asia.
d. Sickle gene offers some protection against malaria.
ANS: D
Sickle cell trait (heterozygosity for hemoglobin S [Hb S]) confers resistance against infection with Plasmodium falciparum. It is believed that this is why the abnormal hemoglobin has such high prevalence in areas where this form of malaria is endemic.
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Fill in the blank(s) with correct word