Why is G6PD important for normal red cell survival?

a. Hemoglobin oxygen affinity is increased in its absence.
b. It is required to regenerate reduced glutathione.
c. It is required for insertion of iron into the protoporphyrin ring to form heme.
d. a Chains are produced in excess in its absence.


ANS: B
G6PD is required to regenerate reduced glutathione in the red cell. Reduced glutathione is essential to generate nicotinamide adenine dinucleotide phosphate, which is necessary to prevent oxidative damage to the red cell.

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