Which statement is accurate regarding the use of nicotinic acid (Niacin) for lowering blood cholesterol levels?
1. It works primarily by lowering LDL and HDL levels.
2. Due to adverse effects, niacin should not be used with statins.
3. Hot flashes are a common side effect when niacin is used in high doses.
4. High doses of 25–30 mg per day are often necessary.
Correct Answer: 3
Rationale: Niacin is used as a vitamin supplement in doses of 25 mg/day. The usual dose of 2–3 grams/day for lowering blood cholesterol levels often results in hot flashes. Niacin lowers LDL levels and increases HDL levels. It is often used with other drugs like the statins.
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