Other than hemoglobin S, name two abnormal hemoglobins that produce a positive sickle solubility test. Explain how they could be differentiated from HbS
What will be an ideal response?
Answer: Hemoglobins C-Harlem and HbI have positive sickle solubility tests (they share the same mutation as hemoglobin S-valine for glutamic at the beta-6 position plus an additional amino acid substitution). To differentiate these from Hb S, hemoglobin electrophoresis should be performed.
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