Describe the process responsible for altering the expression of membrane-bound immunoglobulin to secreted antibody
What will be an ideal response?
Whether immunoglobulin is expressed as a transmembrane-anchored protein or a secreted protein is determined by alternative processing of the heavy-chain RNA transcript. All the heavy-chain C genes contain MC (membrane-coding) exons, which encode the transmembrane region and cytoplasmic tail, and an SC (secretion-coding) exon, which encodes the carboxy terminus of the secreted antibody. The primary RNA transcript contains the MC and SC exons. In naive resting B cells or memory B cells, cleavage and polyadenylation of the transcript at a site (pAm) following the MC exons and deletion of the SC exon by RNA splicing produces the membrane-bound immunoglobulin. On B-cell activation and differentiation into plasma cells, the SC exon is retained in the transcript, and a polyadenylation signal sequence, pAs, immediately following it is used to produce an mRNA encoding the secreted form of the heavy chain.
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Indicate whether the statement is true or false