A client is prescribed dofetilide (Tikosyn) for conversion of atrial fibrillation. The nurse plans to monitor for which adverse effect?

Question

1. Widening of the QT interval
2. Inverted T waves
3. Widening of the PR interval
4. Widening of the QRS complex

Answer 1

Correct Answer: 1
Rationale 1: Like other potassium channel blockers, dofetilide prolongs the refractory period and action potential duration, thus increasing the QT interval.
Rationale 2: T waves are not affected.
Rationale 3: Dofetilide has no effect on the PR interval.
Rationale 4: Dofetilide does not widen the QRS.
Global Rationale: Like other potassium channel blockers, dofetilide prolongs the refractory period and action potential duration, thus increasing the QT interval. Dofetilide has no effect on the T waves or PR interval andit does not widen the QRS.