Describe, using terminology and concepts from ternary receptor models, the difference between a full agonist and a partial agonist.
What will be an ideal response?
Ans: An agonist refers to a drug that activates a neurotransmitter receptor. For the first line of Figure 4.8, a drug acting as an agonist approaches an inactive receptor. The “Before” column represents the inactivity of the receptor by showing a stationary G protein adjacent to the receptor. When the agonist binds to the receptor, the G protein draws close to the receptor, as shown in the Briefly column. The Briefly column for an agonist shows a ternary complex consisting of both a drug and a G protein bound to the receptor. Afterward, as shown in the after column, the G protein separates from the receptor and elicits biological actions within the neuron.
A partial agonist possesses a weaker efficacy for activating receptors than a full agonist. These weaker effects mean that a partial agonist may or may not be able to activate a receptor. In figure 4.9, a partial agonist causes a G protein to shift toward the receptor in the Briefly column. After this, the G protein may separate and elicit effects within a neuron or it may remain bound to the receptor, thereby producing no effects.
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