What role do macrophages have in the neutrophilia that occurs in response to an acute bacterial infection?
A. Macrophages have no role in neutrophilia.
B. When invasion occurs, macrophages mature into neutrophils, increasing their circulating numbers.
C. At the onset of invasion, macrophages secrete a colony-stimulating factor that induces the bone marrow to increase the production and release of neutrophils.
D. Inflammatory damage to macrophages allows release of proteolytic enzymes that enhance liver production of all white blood cell types, including mature, seg-mented neutrophils.
C
The initial response to an acute bacterial invasion is generated by the fixed macrophages in the tissues that have been invaded. These macrophages, in addition to phagocytosing bacteria, pro-duce two classes of substances, chemotaxins to bring other leukocytes to the site of invasion, and colony-stimulating factors to stimulate the bone marrow to increase neutrophil maturation rate and release.
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