Recommend what type of data should be collected and analyzed in a systems biology approach to investigate how a non-pathogenic bacterial strain becomes pathogenic. Describe what scientific fields and methods would be involved in your recommendation
What will be an ideal response?
Answer: A systems biology approach integrates multiple methods and fields to model or analyze a problem. One approach would be to compare the genome and the proteome of non-pathogenic and pathogenic strains of a particular species to find the genes and proteins that are different and may be related to pathogenicity. This research would involve 3rd or 4th generation sequencing, 2D polyacrylamide gel electrophoresis of proteins, and bioinformatics to process and analyze all the data. Further experimentation could involve genetic manipulations to investigate the effect of removing or mutating the implicated genes and biochemical characterization of the implicated proteins. (Answers could vary significantly, but any reasonable discussion of how various "-omic" techniques and methods could be applied to this problem could be acceptable as long as the discussion is consistent and logical, linking the appropriate data types and methods to detect differences between pathogenic and nonpathogenic organisms. The answer should include the definition of systems biology.)
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