A 25-year old female presents with delirium, hyperthermia, and symptoms of central anticholinergic intoxication. She has attended a ìwitches' conventî and ingested some herbal extracts including fruits of the species ìAtropa belladonna.î As one component of her treatment, she receives a dose of physostigmine. Refer to the case above. Physostigmine is preferred over neostigmine because
A) it is a nonpolar compound that penetrates the CNS more easily than neostigmine.
B) it has a shorter half-life than neostigmine, making it more useful for emergency treatment.
C) it has a longer half-life than neostigmine, better matching the half-life of atropine.
D) it is eliminated via the kidneys, and dosage is not critical with compromised liver function.
E) it is eliminated via the liver, and dosage is not critical with compromised renal function.
A) it is a nonpolar compound that penetrates the CNS more easily than neostigmine.
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