A patient with a urinary tract infection is also receiving anticoagulant therapy with warfarin. Which of the following statements most accurately describes the efficacy of fluoroquinolones for this patient?
a. Fluoroquinolones have no effect on the prothrombin time.
b. Fluoroquinolones shorten the prothrombin time.
c. Fluoroquinolones prolong the prothrombin time.
d. Fluoroquinolones have an uncertain effect on prothrombin time.
ANS: C
Quinolones enhance the action of warfarin, so prothrombin time would be prolonged, and close monitoring of prothrombin time (PT) and international normalized ratio (INR) levels is warrant-ed. Levofloxacin used concomitantly with warfarin may cause QT prolongation.
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