Select the mechanism of action of topiramate (Topamax).
A. Topiramate reduces the T-type calcium currents in the thalamus, which reduces the occurrence of seizures.
B. Topiramate prolongs the inactivation period of potassium (K+) channels in the nerve membrane, leading to a reduction in the generation of high-frequency repetitive firing of action potentials from neurons involved in initiating seizures.
C. Topiramate shortens the inactivation period of sodium ion (Na+) channels in the nerve membrane, leading to a reduction in the generation of high-frequency repetitive firing of action potentials from neurons involved in initiating seizures.
D. Topiramate interferes with the action of Na+ ions and the generation of high-frequency action potentials. The drug may also increase the inhibitory actions of gamma-aminobutyric acid.
Answer: D
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