Which of the following produce their glucose-lowering effect by decreasing insulin resistance and increasing insulin sensitivity? Select all that apply
A) Rosiglitazone (Avandia)
B) Metformin (Glucophage)
C) Pioglitazone (Actos)
D) Miglitol (Glyset)
E) Acarbose (Precose)
Ans: A, C
Feedback:
The thiazolidinediones, rosiglitazone (Avandia) and pioglitazone (Actos), produce their glucose-lowering effect by decreasing insulin resistance and increasing insulin sensitivity. The alpha-glucosidase inhibitors, acarbose (Precose) and miglitol (Glyset), produce their glucose-lowering effects by delaying the digestion and absorption of carbohydrates in the intestine. Metformin sensitizes the liver to circulating insulin levels and reduces hepatic glucose production.
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