What tests are best to distinguish thrombotic thrombocytopenic purpura from DIC when a patient has schistocytes?

a. Platelet count and morphology
b. Bone marrow aspirate and biopsy
c. Reticulocyte count and haptoglobin
d. PT and PTT


ANS: D
The best tests, of those listed, to distinguish thrombotic thrombocytopenic purpura from acute DIC are the PT and PTT. Both will be prolonged in DIC, but not affected in thrombotic thrombocytopenic purpura.

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