A highly consistent finding across human experimental studies is a difficulty in establishing a dose-effect relationship between cannabis potency and the rate of human self-administration or subjective ratings of ‘high’. What factor contributes to
this difficulty?
a. Some experimental studies, especially early ones, administered a truncated range of cannabis doses that were all very low in THC concentration (e.g., 0.2% vs. 0.4% vs. 0.8%).
b. Individual personality traits, such as extroversion and neuroticism, influence subjective ratings of ‘high’.
c. Some experimental studies allow for ad libitum cannabis smoking, whereas others use experimenter-controlled cannabis administration, resulting in variability in dose delivery.
d. Participants’ ratings of cannabis ‘high’, ‘potency’, and ‘liking’ do not correlate with the frequency with which they smoke cannabis cigarettes.
e. All of the above factors contribute to the difficulty in establishing a cannabis dose-effect relationship.
Answer: E
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