A client is prescribed a medication that requires the cytochrome P450 3A4 enzyme system for absorption. Because of this, what should the nurse instruct the client when taking this medication?
a. Take on an empty stomach
b. Avoid all use of grapefruit juice
c. Take this medication with grapefruit juice
d. Avoid eating for several hours after taking
b. Avoid all use of grapefruit juice
Grapefruit juice inhibits the cytochrome P450 3A4 enzyme system responsible for "first-pass metabolism" of many drugs. The inhibition of the enzyme allows more drug to be absorbed than normally would occur, elevating plasma drug levels. The cytochrome P450 3A4 enzyme is not identified as being affected by the presence or absence of food.
You might also like to view...
What is the caloric value of vitamins?
a. 9 cal/g b. 4 cal/g c. 0 cal/g d. 7 cal/g
The nurse suspects a newborn has a fractured clavicle. What are signs of a fractured clavicle? (Select all that apply.)
a. An asymmetric Moro reflex b. Limited use of the affected arm c. Crying when the arm is moved d. Muscles of the hand are paralyzed e. The arm hangs limp alongside the body
In order for the nurse to convey healthcare information to an adolescent, it is most important for the adolescent to ______ the nurse
a. like b. be friends with c. trust d. spend quality time with
Which of the following terms is used to describe the breakdown of complex molecules into simpler ones?
a. Anabolism b. Synthesis c. Homeostasis d. Catabolism