Multiple myeloma is a plasma cell tumor in which a clone of malignant plasma cells produces large amounts of immunoglobulin. With all this excess immunoglobulin, how can a person with multiple myeloma be immunodeficient?

A.
All the immunoglobulin produced is most likely specific to one antigen. This limits the ability to respond to the diversity of antigens we encounter.

B. The multiplication of the malignant plasma cells may crowd out normal production of other immune cells required for protective responses.
C. The massive overproduction of immunoglobulin impairs the kidneys, preventing production of the correct hormones from the kidneys to balance immune system cell production from the bone marrow.
D.
Through a negative feedback loop, the large amount of immunoglobulin tricks the immune system into thinking it's making a strong response that is needed. As such, it shuts down production of other responses that might truly BE needed to fight off a pathogen.

E.
All the immunoglobulin produced is most likely specific to one antigen. This limits the ability to respond to the diversity of antigens we encounter AND the multiplication of the malignant plasma cells may crowd out normal production of other immune cells required for protective responses.


E.

Biology & Microbiology

You might also like to view...

A mycorrhiza is a relationship between a fungus and

a. another fungus. b. animals. c. plants. d. protists.

Biology & Microbiology

Rubulavirus falls under which group of the ICTV nomenclature system?

A. Subfamily B. Family C. Genus D. Order

Biology & Microbiology

Dissimilative iron-reducing bacteria use a variety of metals as

a. electron donors during respiration. b. electron acceptors during respiration. c. electron acceptors during fermentation. d. electron acceptors during sulfate reduction.

Biology & Microbiology

The production of uric acid is advantageous to birds because uric acid __________.

a. is very soluble in water and takes very little energy to produce b. has low toxicity, requires little water to excrete, and can be safely stored as an embryo develops in an egg c. contributes to the production of the egg shell and can thus serve two purposes d. takes less energy to produce than urea e. has low toxicity, requires little water to excrete, can be safely stored as an embryo develops in an egg, and takes less energy to produce than urea

Biology & Microbiology