Which type of drug is most effective in the treatment of erectile dysfunction (ED)?
a. Phosphodiesterase inhibitors
b. Antiandrogen agents
c. Sympathomimetic agents
d. Alpha-1 adrenergic blocking agents
ANS: A
Sildenafil (Viagra), a phosphodiesterase inhibitor, increases cyclic guanosine monophosphate concentrations in the corpus cavernosum, which results in smooth muscle relaxation and greater blood flow into the corpus cavernosum, producing an erection. Antiandrogen agents, sympathomimetic agents, and adrenergic blocking agents are not effective in treating ED.
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