What statement best represents infectious mononucleosis?
a. Herpes simplex type 2 is the principal cause.
b. A complete blood count shows a characteristic leukopenia.
c. A short course of ampicillin is used when pharyngitis is present.
d. Clinical signs and symptoms and blood tests are both needed to establish the diagnosis.
ANS: D
The characteristics of the disease—malaise, sore throat, lymphadenopathy, central nervous system manifestations, and skin lesions—are similar to presenting signs and symptoms in other diseases. Hematologic analysis (heterophil antibody and monospot) can help confirm the diagnosis. However, not all young children develop the expected laboratory findings. Herpes-like Epstein-Barr virus is the principal cause. Usually, an increase in lymphocytes is observed. Penicillin, not ampicillin, is indicated. Ampicillin is linked with a discrete macular eruption in infectious mononucleosis.
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