A woman with poorly controlled type 1 diabetes has been admitted to a hospital unit for the treatment of ketoacidosis. Place the following events in the pathophysiology of ketoacidosis in the correct chronological order. Use all the options
A) Decrease in pH
B) Breakdown of triglycerides
C) Low serum insulin levels
D) Ketone production by the liver
E) Production of fatty acids and glycerol
Ans:
C, B, E, D, A
Feedback:
During ketoacidotic episodes, the lack of insulin leads to mobilization of fatty acids from adipose tissue because of the unsuppressed adipose cell lipase activity that breaks down triglycerides into fatty acids and glycerol. The increase in fatty acid levels leads to ketone production by the liver and ultimately metabolic acidosis.
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