Using de novo mutations, explain why older fathers are more likely to have children with autism or schizophrenia compared to younger fathers.
What will be an ideal response?
The ideal answer will include:
1. Older men are more likely to have mutations in the sperm cells that can be passed on to the child (de novo mutations).
2. Because sperm cells are regenerated about twice per month, the likelihood of small copying errors (mutations) increases.
3. These mutations are more likely to lead to outcomes such as autism or schizophrenia in offspring.
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