Which benzodiazepine has a greater advantage for treatment of alcohol withdrawal syndrome (AWS) because of its longer half-life and high lipid solubility?
a. Ativan c. Propofol
b. Midazolam d. Valium
D
Management of alcohol withdrawal involves close monitoring of AWS-related agitation and administration of IV benzodiazepines, generally diazepam (Valium) or lorazepam (Ativan). Diazepam has the advantage of a longer half-life and high lipid solubility. Lipid-soluble medications quickly cross the blood–brain barrier and enter the central nervous system to rapidly produce a sedative effect. Midazolam is the recommended drug for use in alleviating acute agitation but is known to cause seizures with AWS because of rapid withdrawal. Propofol is indicated for sedation use.
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Fill in the blank(s) with correct word
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