When administering vincristine, the nurse knows that its dose-limiting toxicity primarily affects what system?
1. Renal
2. Pulmonary
3. Cardiac
4. Central nervous system
Correct Answer: 4
Rationale 1: Although important, the renal system is not the system primarily affected by vincristine.
Rationale 2: Although important, the pulmonary system is not the system primarily affected by vincristine.
Rationale 3: Although important, the cardiac system is not the system primarily affected by vincristine.
Rationale 4: The system primarily affected by the dose-limiting toxicity of vincristine is the central nervous system.
Global Rationale: The major dose-limiting toxicity of vincristine is neurotoxicity. The other systems may be affected, but not with the major dose-limiting effects.
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