A two-year-old child with a fever is prescribed amoxicillin clavulanate 250 mg/5 ml three times daily by mouth for ten days for otitis media. To guard against antibiotic resistance, the nurse instructs the parent to:
1. Give the antibiotic for the full ten days.
2. Measure the prescribed dose in a household teaspoon.
3. Spread the dose evenly during daylight hours.
4. Stop the antibiotic when the child is afebrile.
1
Rationale 1: Antibiotics must be administered for the full number of days ordered to prevent mutation of resistant strains of bacteria.
Rationale 2: A household teaspoon could contain less than 5 cc, and the full dose must be given.
Rationale 3: The antibiotic should be administered around the clock to maintain a blood level.
Rationale 4: Stopping the antibiotic before the prescribed time will permit remaining bacteria to reproduce, and the otitis media will return, possibly with antibiotic-resistant organisms.
Global Rationale:
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