Your research project involves the characterization of a recently identified transcription factor. As part of your project, you want to determine if this transcription factor binds directly to any of the general transcription factors. Unfortunately, you are having trouble expressing the full-length protein. What approach may help achieve your research goal?

A. You must find a way to express the full-length protein, since transcription factor functions do not lie in separate domains.
B. Express and purify only the DNA-binding domain, and test for binding.
C. Identify the RNA that mediates the protein-protein binding.
D. Express and purify only the activation domain, and test for binding.


Answer: D

Biology & Microbiology

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