Brittle bone disease (osteogenesis imperfecta) usually results from a collagen deficiency. Explain how a collagen deficiency affects bone structure
What will be an ideal response?
The predominant protein fibers in bone are collagen fibers. Collagen fibers form cross-links with one another and help bone to resist torsion (twisting) and tensile (pulling or stretching) forces. They also align with hydroxyapatite crystals, significantly enhancing the hardness of bone. Collagen fibers are one of the most important components of the bone ECM in terms of strength; when these fibers become inadequate or defective, bone weakens and any minor twisting force may break it.
You might also like to view...
What provides the shortest-term mechanism for preventing acid-base imbalances in the body? The longest-term mechanism?
What will be an ideal response?
Which type of blood vessels carry blood away from the heart?
A) arteries B) veins C) capillaries
Which of the following forms the fetal portion of the placenta?
A. Chorion B. Amnion C. Allantois D. Embryoblast E. Yolk sac
White blood cells that are increased in allergic individuals are the
A) neutrophils. B) eosinophils. C) platelets. D) lymphocytes. E) monocytes.