A patient is being treated for Parkinson's disease and has been prescribed both levodopa (L-dopa) and carbidopa (Lodosyn). Why is this course of combination treatment most effective?
A) Levodopa restores dopamine and carbidopa decreases peripheral breakdown of levodopa.
B) Levodopa decreases the toxic effects of carbidopa to reduce the extrapyramidal reaction.
C) Carbidopa increases the peripheral breakdown of levodopa to hasten its onset and peak.
D) Levodopa and carbidopa, when combined, enhance voluntary movement to improve gait.
A
Feedback:
Levodopa restores dopamine levels and, in combination with carbidopa, decreases the peripheral breakdown of levodopa and allows more to reach the brain. Levodopa does not decrease the toxic effects of carbidopa to reduce the extrapyramidal reaction. Carbidopa does not increase the peripheral breakdown of levodopa to increase its effectiveness. Levodopa and carbidopa combined do not exacerbate abnormal voluntary movement to increase gait.
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