A nurse reviews the medication list of an older adult. Which of the following age-related changes leads to a slower drug clearance?
A) Increase in sensitivity to bioactive substances
B) Elimination half-time is likely to be faster.
C) Increase in glomerular filtration rate
D) Decrease in hepatic blood flow
Ans: D
The older adult is not more sensitive to bioactive substances. Elimination is likely to be slower. There is an age-related decline in hepatic blood flow that impacts pharmacokinetics, as well as the glomerular filtration rate.
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