Which vaccines are of the whole-agent type?
1. Diphtheria and tetanus
2. Measles and mumps
3. HPV and pertussis
4. Influenza and hepatitis A
Correct Answer: 4
Rationale 1: These agents are examples of toxin vaccines.
Rationale 2: Measles and mumps are not whole-agent vaccines.
Rationale 3: These are examples of subunit vaccines.
Rationale 4: Whole-agent vaccines include influenza and hepatitis A.
Global Rationale: Whole-agent vaccines consist of microbes killed by heat or chemicals. Inactivated or killed vaccines are safer than live vaccines because the organism is unable to replicate, mutate, or cause disease. Subsequent booster doses are required to maintain immunity if inactivated or killed vaccines are used. Examples of inactivated or killed vaccines include the influenza and hepatitis A vaccines. Diphtheria and tetanus are toxin vaccines. Measles and mumps are not whole-agent vaccines. HPV and pertussis are subunit vaccines.
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