A 41-year-old woman has made the recent decision to start a family and is eager to undergo testing to mitigate the possibility of having a child with Down syndrome. Which of the following tests is most likely to provide the data the woman seeks?
A) Genetic testing of the woman
B) Genetic testing of the woman and the father
C) Prenatal blood tests
D) Ultrasonography
Ans: C
Feedback:
Down syndrome is a result of chromosomal abnormality and is not a single-gene disorder. As a result, genetic testing of the mother and/or father is not relevant. Ultrasonography does not have predicative value for Down syndrome, but blood tests such as ?-fetoprotein, human chorionic gonadotropin (HCG), unconjugated estriol, inhibin A, and pregnancy-associated plasma protein A have helped ascertain the risks.
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