Although pregnant women do not typically exhibit hyperthyroidism, maternal total T4 levels increase during pregnancy. This benign increase in total T4 is due to:
A. increased synthesis of thyroid hormone–binding globulin (TBG)
B. increased pituitary deiodinase activity
C. decreased placental deiodinase activity
D. resistance to thyroid hormone receptor signaling
E. decreased excretion of thyroid hormone by kidney
ANS: A
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