A patient is taking sertraline (Zoloft) for depression, and the provider orders azithromycin (Zithromax) to treat an infection. What will the nurse do?
a. Contact the provider to discuss an alternative to azithromycin.
b. Request an order for a different antidepressant medication.
c. Request an order to reduce the dose of sertraline.
d. Withhold the sertraline while giving the azithromycin.
ANS: A
Both sertraline and azithromycin prolong the QT interval, and when taken together, they increase the risk of fatal dysrhythmias. Because the antibiotic is used for a short time, it is correct to consider using a different antibiotic. Reducing the dose of sertraline does not alter the combined effects of two drugs that lengthen the QT interval. Sertraline should not be stopped abruptly, so withholding it during antibiotic therapy is not indicated.
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