Which of the following antibiotics are bactericidal in time-dependent fashion? I. aminoglycosides II. fluoroquinolones III. vancomycin IV. beta-lactams
A. I, II only
B. II, III only
C. III, IV only
D. I, II, IV only
ANS: C
A. Incorrect response: See explanation C.
B. Incorrect response: See explanation C.
C. Correct response: Aminoglycosides and fluoroquinolones are bactericidal in a concentration-dependent fashion with postdose effect. Beta-lactams and vancomycin are bactericidal in time-dependent manner with no postantibiotic effect.
D. Incorrect response: See explanation C.?
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