Which patients would be candidates for the use of dronabinol (Marinol) to treat nausea and vomiting? (Select all that apply.)
a. A patient with a history of a psychiatric disorder
b. A patient with acquired immunodeficiency syndrome (AIDS)–induced anorexia
c. A patient with chemotherapy-induced nausea and vomiting
d. A patient with nausea who has used marijuana in the past
e. A patient with postoperative nausea and vomiting
ANS: B, C, D
Two cannabinoids have been approved for medical use in the United States for AIDS-induced anorexia and CINV. Because these drugs do not produce the same "high" that smoking marijuana does, their use is not contraindicated in patients who have used marijuana in the past. They do cause potentially unpleasant effects, such as temporal disintegration, dissociation, depersonalization, and dysphoria, so they are contraindicated in patients with psychiatric disorders. They are not approved for postoperative nausea and vomiting.
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