When quizzing obstetrical nursing students regarding tissues affected by mitochondrial DNA mutations, the instructor accepts which of the following responses? Select all that apply
A) Retinal degeneration
B) Deafness
C) Cardiac valve abnormalities
D) Absent testes
E) Palatal abnormalities
Ans: A, B
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Mitochondrial DNA mutations generally affect tissues and organs that are highly dependent on oxidative phosphorylation to meet their high needs for metabolic energy. Thus, mitochondrial diseases frequently affect the brain and neuromuscular system and produce encephalomyopathies, retinal degeneration, loss of extraocular muscle function, lactic acidosis, and deafness.
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