Which medications reduce acid secretion by binding irreversibly to the enzyme H+, K+-ATPase?(Select all that apply.)
1. Omeprazole (Prilosec)
2. Magnesium hydroxide (Milk of Magnesium)
3. Famotidine (Pepcid)
4. Ranitidine (Zantac)
5. Pantoprazole (Protonix)
1, 5
Rationale 1: Omeprazole (Prilosec) is a PPI, which reduces acid secretion by binding irreversibly to the enzyme H+, K+-ATPase.
Rationale 2: Magnesium hydroxide (Milk of Magnesium) is an antacid, which neutralizes acid.
Rationale 3: Famotidine (Pepcid) is an H2-receptor blocker, which reduces acid secretion.
Rationale 4:Ranitidine (Zantac) is an H2-receptor blocker, which reduces acid secretion.
Rationale 5:Pantoprazole (Protonix) is a PPI, which reduces acid secretion by binding irreversibly to the enzyme H+, K+-ATPase
Global Rationale: PPIs reduce acid secretion by binding irreversibly to the enzyme H+, K+-ATPase. Omeprazole (Prilosec) and pantoprazole (Protonix) are two PPIs.
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