A student nurse asks the charge nurse the definition of a prodrug. What is the best response by the charge nurse?

1. A prodrug is a brand name drug.
2. A prodrug is not absorbed by the body.
3. A prodrug is the first drug developed in a drug class.
4. A prodrug requires metabolism to make it active.


4

Rationale 1: A prodrug requires metabolism to make it active. In these cases, as the drug is broken down by chemical reactions of metabolism, the products formed by the breakdown produce a more intense response than does the original drug.
Rationale 2: A prodrug requires metabolism to make it active. In these cases, as the drug is broken down by chemical reactions of metabolism, the products formed by the breakdown produce a more intense response than does the original drug.
Rationale 3: This is the definition of a prototype drug.
Rationale 4: In these cases, as the drug is broken down by chemical reactions of metabolism, the products formed by the breakdown produce a more intense response than does the original drug.

Global Rationale: A prodrug requires metabolism to make it active. In these cases, as the drug is broken down by chemical reactions of metabolism, the products formed by the breakdown produce a more intense response than does the original drug. A prodrug is not necessarily a brand name drug. A prodrug is absorbed by the body. A prototype drug, not a prodrug, is the first drug developed in a drug class.

Nursing

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