Forty-four-year old Danielle Bouvier is on the waiting list for a kidney transplant and is receiving weekly dialysis. Her HLA type is: HLA-A: 0101/0301; HLA-B: 0702/0801; HLA-DRB1: 0301/0701
Today, Danielle's physician informed her that several potential kidney donors are available. Which of the following would be the most suitable?
a. A: 0301/0201; B: 4402/0801; DRB1: 0301/0403
b. A: 0301/2902; B: 1801/0801; DRB1: 0301/0701
c. A: 2902/0201; B: 0702/0801; DRB1: 0301/13011
d. A: 0101/0101; B: 5701/0801; DRB1: 0701/0701
e. A: 0101/0301; B: 0702/5701; DRBA: 0403/0301.
Rationale: The correct answer is d. The better the match in HLA class I and class II allotypes between the donor and the recipient, the better the outcome of the transplantation. Donor ‘d' has five out of six alleles in common for HLA-A, HLA-B, and DRB. Donors ‘b' and ‘e' share only four, and donors ‘a' and ‘c' only three.
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