Which of the following explain why infections with influenza virus erode immunological memory over time? (Select all that apply.)
a. Influenza is a highly mutable virus that changes its epitope composition.
b. A compensatory immune response to new epitope variants is suppressed in naive B cells.
c. The antibody response is directed only toward new epitope variants, resulting in a decreased memory response.
d. Cross-linking of B-cell receptor and Fc?RIIB1 on memory B cells induces anergy.
e. Naive B cells are suppressed by cytokines made by memory B cells.
a, b
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