Felicity is a very busy 29-year-old woman in a professional career. She has diabetes mellitus and is also pregnant for the first time. Explain the potential teratogenic effect of folic acid deficiency on the developing fetus. What other risk factor is not

Because of her busy schedule, it was over 3 weeks after missing her menstrual cycle when she visited her family doctor to have the pregnancy confirmed. Felicity became very concerned when her physician asked if she had been taking folic acid. It was all Felicity could do to remember to manage her insulin levels, and taking folic acid supplements was something she had not even considered. Her doctor told her to take 600 ?g of folic acid daily and advised Felicity to return later for maternal serum marker testing.

Explain the potential teratogenic effect of folic acid deficiency on the developing fetus. What other risk factor is noteworthy in Felicity's case?

What is the benefit of maternal serum marker testing? What other test would be particularly useful to monitor the development of Felicity's baby in this situation?

When is the fetus most vulnerable to the effects of teratogens and why?


Folic acid deficiency is implicated in neural tube defects such as spina bifida, anencephaly, and encephalocele. Diabetes mellitus in the mother is also a risk factor for neural tube defects in the developing fetus.

Maternal serum marker testing measures AFP in the maternal blood. AFP is produced by the fetus and circulates freely when fetal membranes and blood vessels are exposed. It is therefore elevated with neural tube and ventral wall defects. Ultrasound is another useful test because it is able to visually detect fetal cranial and spinal defects in utero.

Teratogens produce their most detrimental effects on the fetus during the period of organogenesis. The most rapid time of organ development occurs from day 15 to day 60 after conception

Nursing

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