A patient asks the surgical nurse why the anesthesiologist asked if a member of his family ever had hyperthermia during surgery. The nurse responds that malignant hyperthermia is a life-threatening crisis that:
A) is transmitted in an autosomal recessive pattern.
B) is transmitted in an autosomal dominant pattern.
C) is an X-linked trait.
D) is caused by an extra chromosome.
B) is transmitted in an autosomal dominant pattern.
Explanation: A) Malignant hyperthermia is a rare, life-threatening hypermetabolic crisis that can occur when a genetically susceptible individual is exposed to an anesthetic agent that has adrenergic, anticholinergic, serotonergic, and antidopaminergic properties. The reaction is caused by a mutation in the type 1 ryanodine receptor (RYR1) gene. This mutation is transmitted in an autosomal dominant pattern.
B) Malignant hyperthermia is a rare, life-threatening hypermetabolic crisis that can occur when a genetically susceptible individual is exposed to an anesthetic agent that has adrenergic, anticholinergic, serotonergic, and antidopaminergic properties. The reaction is caused by a mutation in the type 1 ryanodine receptor (RYR1) gene. This mutation is transmitted in an autosomal dominant pattern.
C) Malignant hyperthermia is a rare, life-threatening hypermetabolic crisis that can occur when a genetically susceptible individual is exposed to an anesthetic agent that has adrenergic, anticholinergic, serotonergic, and antidopaminergic properties. The reaction is caused by a mutation in the type 1 ryanodine receptor (RYR1) gene. This mutation is transmitted in an autosomal dominant pattern.
D) Malignant hyperthermia is a rare, life-threatening hypermetabolic crisis that can occur when a genetically susceptible individual is exposed to an anesthetic agent that has adrenergic, anticholinergic, serotonergic, and antidopaminergic properties. The reaction is caused by a mutation in the type 1 ryanodine receptor (RYR1) gene. This mutation is transmitted in an autosomal dominant pattern.
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