The nurse on an oncology unit is caring for a patient with lung cancer. Prior to the next dose of cisplatin (Platinol-AQ), which antiemetic would the nurse most likely administer to the patient?
a. Metoclopramide (Reglan)
b. Droperidol (Inapsine)
c. Ondansetron (Zofran)
d. Prochlorperazine
C
Serotonin-receptor antagonists, such as ondansetron, are the most effective drugs available for suppressing nausea and vomiting caused by cisplatin and other highly emetogenic anticancer drugs.
Metoclopramide is used to suppress postoperative nausea and vomiting and emesis associated with cancer chemotherapy. However, it would not be the drug of choice in this situation.
Butyrophenones, such as droperidol, are used as antiemetics; however, they are not the most ef-fective antiemetics for cancer patients. They typically are used for postoperative nausea.
Phenothiazines, such as prochlorperazine, may be used with cancer chemotherapy and surgery, but they are not as effective for emesis caused by cisplatin.
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