Which of the following enhance placental transfer of drugs? Select all that apply
a. Lipid solubility
b. Nonionized nature of the substance
c. Lack of significant albumin binding
d. Increased diffusion distance
e. High molecular charge
f. High molecular weight
g. Higher maternal-to-fetal gradient
h. Increased placental blood flow
ANS: A, B, C, G, H
Factors that enhance the placental transfer of drugs include lipid solubility, nonionized substanc-es, lack of significant albumin binding, higher maternal-to-fetal gradient, and increased placental blood flow. Increased diffusion distance, high molecular charge, and high molecular weight are factors that inhibit placental transfer of drugs.
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