Describe the relationship between single nucleotide polymorphisms and haplotypes and explain how each is used in genome-wide association studies

What will be an ideal response?


Genome-wide association studies look for an association between the single nucleotide polymorphism markers and a trait. Haplotypes are combinations of SNPs located so close to each other on a chromosome that they are very often inherited together. In GWAS, researchers scan tens of thousands of genomes to see whether a particular haplotype is found significantly more often in people with a trait than in people without the trait. If so, a gene controlling that trait may be near the chromosome location of these SNPs, and candidate genes near the SNPs can be investigated.

Biology & Microbiology

You might also like to view...

Impaired vision after a blow to the head implies damage to the vision processing center in the brain. Which region of the brain controls vision?

A. frontal lobe B. parietal lobe C. temporal lobe D. occipital lobe E. brainstem

Biology & Microbiology

Which species is considered to be the most ancient?

a. Homo erectus b. Australopithecus afarensis c. Australopithecus sediba d. Homo sapiens e. Sahelanthropus tchadensis

Biology & Microbiology

Females of various species shop around for males

that a. have the best burrows. b. offer superior nuptial gifts. c. make showy displays. d. include all of these. e. include none of these.

Biology & Microbiology

What type of muscle fibers will be found in large percentages in the leg muscles of a person who excels at weight lifting but does not do well at running marathons?

A) slow-twitch B) fast-twitch C) intermediate D) high-density

Biology & Microbiology