Provide an explanation of why it is believed that MHC class I genes are the evolutionary ancestors of MHC class II genes
What will be an ideal response?
MHC class I molecules not only have the role of presenting antigen to T cells, but they also possess additional functions in the body not associated with MHC class II molecules. For example, they participate in iron homeostasis, IgG uptake in the gastrointestinal tract, and the regulation of NK-cell function in innate immunity. In addition, MHC class I and class I-like genes are not confined to chromosome 6, in contrast with MHC class II genes. Finally, vertebrates exist (such as Atlantic cod) that have only MHC class I genes in their genome, and lack MHC class II genes.
You might also like to view...
Arterioles lead into capillaries, the connecting link between arteries and veins
Indicate whether the statement is true or false.
The nurse suspects nocturnal hypoglycemia in a diabetic client. Which symptoms can the nurse expect to observe in this client? Select all that apply
1. Sleep disturbance 2. Vivid nightmares 3. Severe dehydration 4. Morning headache 5. All of the above
Where does the herpes simplex virus (HSV) remain during its dormant stage?
1. Epithelium layer 2. Sacral spinal nerves 3. Dorsal ganglion of sensory nerves 4. All of the above
One major cause of stroke, bleeding, accounts for
A. 10% of all strokes. B. 20% of all strokes. C. 37% of all strokes. D. 48% of all strokes.