Which statement is true regarding hormone antagonists?
1. They are cytotoxic.
2. They enhance substances essential for hormone growth.
3. They produce similar debilitating adverse effects that other antineoplastics produce.
4. They can produce debilitating adverse effects at high doses for prolonged periods.
Correct Answer: 4
Rationale 1: They are not cytotoxic.
Rationale 2: They block substances essential for hormone growth.
Rationale 3: They produce few debilitating adverse effects that other antineoplastics produce.
Rationale 4: This classification of medications can produce debilitating adverse effects when given at high doses for prolonged periods of time.
Global Rationale: In general, the hormones and hormone antagonists act by blocking the substances essential for tumor growth. Because these drugs are not cytotoxic, they produce few of the life-threatening toxic effects of antineoplastics from other classes. They can, however, produce significant adverse effects when given at high doses for prolonged periods.
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